So, the metabolite is accountable for about twenty% of sildenafil's motion. Sildenafil is excreted as metabolites predominantly inside the feces (about 80% of administered oral dose) also to a lesser extent within the urine (close to 13% from the administered oral dose). If taken that has a significant-Fats food, absorption is decreased; the time taken to reach the most plasma focus will increase by all around just one hour, and the utmost concentration alone is reduced by almost one-3rd.[fifty two]
Even though the conversation between other protease inhibitors and sildenafil has not been researched, their concomitant use is predicted to enhance sildenafil ranges.
Hvis dose du skal ta kommer an på flere faktorer som risiko for bivirkninger, alvorlighetsgraden av din impotens og hva din impotens skyldes.
Merk: Beslutninger om behandling vurderes i fellesskap av forskriver og pasient beneath konsultasjonen. Den endelige avgjørelsen vil imidlertid alltid være forskriverens.
The signify constant state quantity of distribution (Vss) for sildenafil is a hundred and five L, indicating distribution to the tissues. Sildenafil and its significant circulating N-desmethyl metabolite are both close to 96% sure to plasma proteins. Protein binding is independent of overall drug concentrations.
At 24 several hours the plasma levels of sildenafil had been nonetheless approximately two hundred ng/mL, when compared with about five ng/mL when sildenafil was dosed by yourself. This really is consistent with ritonavir's marked outcomes with a broad choice of P450 substrates. VIAGRA had no effect on ritonavir pharmacokinetics [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS].
Injection Liquid. Sildenafil injection is frequently presented by a Health care company in a healthcare facility or clinic. You won't retail store it in your own home.
VIAGRA isn't going to protect you or your lover from obtaining sexually transmitted disorders, such as HIV—the virus that causes AIDS.
The next occasions happened in < 2% of clients in controlled medical trials; a causal partnership to VIAGRA is unsure. Reported functions consist of All those having a plausible relation to drug use; omitted are slight events and reviews way too imprecise to generally be significant:
Snakk med lege fileør du tar legemidlet dersom du har høyt blodtrykk som ikke er godt behandlet, eller har uregelmessige hjerteslag/hjertebank.
This document will not have all feasible Negative effects and Other folks may possibly take place. Examine along with your medical doctor For added specifics of Uncomfortable side effects.
abnormal eyesight, like improvements in colour eyesight (for instance possessing a blue shade tinge) and blurred eyesight
Equivalent effects on hypertension have been mentioned with twenty five mg, 50 mg and a hundred mg of VIAGRA, as click here a result the consequences will not be associated with dose or plasma levels in this dosage range. Greater outcomes were recorded amongst clients acquiring concomitant nitrates [see CONTRAINDICATIONS].
[seventy five] A single writer notes that Even though the impact of Viagra is simply restricted to penile blood vessels, adverts routinely use imagery of couples hugging, smiling and dancing, Together with the creator declaring that pharmaceutical corporations were deceptive in the use of this kind of advertisements.[76]